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Immunology Book Suggestion

Immunology Book Suggestion



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Which book will give a brief account about B-cell development so that it covers two questions about the following cells:

  • Plasmablast
  • Plasma cell
  • Memory B cell
  • Marginal zone (MZ) B cell
  • B-1 cell
  • B-2 cell
  • Regulatory B (Breg) cell

    1. Where do they lie in the course of B-cell development and differentiation?

    2. What are their functions (outline)?

P.S. I need to know the development part in details rather than the functions.


The best immunology book hands down is Janeway's Immunobiology. There is no debate among the immunology community. The middle section is devoted to B cell development.


I have found a book that explains in a quiet simple way the entire B-cell development and differentiation stepwise and covers the two questions I was looking for. It is Kuby Immunology, 7th Edition.

Except the Breg cells which is a recent discovery every cell was well discussed. I went through this to learn what the functions of B reg are.


Biology Notes on Immune System | Immunology

The below mentioned article provides notes on immune system.

Immune Response:

Any foreign protein, toxin of parasites, bacte­ria and viruses, when enter into the body, they interfere with host physiological processes and produce harmful effects. The “Chemical defense” mechanism of host organism that operates against such effects of parasites and others is called immune reaction or immune response.

The branch of life science which deals with immune reaction is known as immunology.

Components of Immune System:

The immune system consists of a network of diverse organs and tissue which vary structurally as well as functionally from each other. These organs remain spreaded throughout the body. Basically, immune system is a complex network of lymphoid organs, tissues and cells.

These lym­phoid organs can be categorized under three types depending upon their functional aspects:

ii. Secondary lymphoid organ.

iii. Tertiary lymphoid organ.

White blood cells or leukocytes are the basic cell types which help to give rise to different types of cells which participate in the development of immune response (Fig. 2.1). WBC are classified into granulocytes and agranulocytes depending on the presence or absence of granules in the cyto­plasm.

Agranular leukocytes are of two types, viz., lymphocytes and monocytes. Lymphocytes play pivotal role in producing defensive molecules of immune system. Out of all leukocytes, only lymphocytes possess the quality of diversity, specificity, memory and self-non self recognition as various important aspects of immune response.

Other cell types remain as accessory one help to activate lymphocytes, to generate various immune effector cells, to increase the rate of anti­gen clearance etc. (Fig. 2.2).

Mature blood cells have a relatively short span of life and consequently the population must be continuously replaced by the progeny of stem cells produced in the hemopoietic (Gr. haema, blood poiesis, a making) organs.

Initiation of Hematopoiesis:

Hematopoiesis begins in the yolk sac in the first week of embryonic development. Here yolk-sac stem cells differentiate into primitive erythroid cells containing embryonic haemoglobin. In the third month of gestation, the stem cells migrate from the yolk sac to the foetal liver and then to the spleen these two organs have major roles in hematopoiesis from third to the seven month of gestation. As gestation continues, the bone marrow becomes the major hemopoietic organ. By birth hematopoiesis has ceased within the liver and spleen.

Stem cells, Growth factors and Differen­tiation:

It is thought that all blood cells arise from a single type of stem cell is the bone marrow. Bone marrow can produce all blood cell types. It is called a pluripotential or pluripotent stem cell. This cell proliferates and differentiates and giving rise to lymphoid and myeloid stem cells. Both of these two types of stem cells are called multi- potential stem cells.

Subsequent differentiation of lymphoid and myeloid stem cells generate committed progeni­tor cells for each type of mature blood cells. These progenitor cells or progenitor stem cells have lost the capacity of self-renewal and are committed to a particular cell lineage.

Progenitor commitment depends on the acqui­sition of responsiveness to particular growth fac­tors, when appropriate growth factors are present. These progenitor cells proliferate and differen­tiate, giving rise to the corresponding type of mature red or white blood cells.

In adult bone marrow, the hemopoietic cells grow and mature on a meshwork of stromal cells, (fat cells, endothelial cells, fibroblasts and macrophages) which are non-hematopoietic in nature. Stromal cells influence the hematopoietic stem cell differentiation by providing a hemo­poietic inducing microenvironment consisting of a cellular matrix and factors that promote growth and differentiation.

As hematopoietic stems cells differentiate in this microenvironment, their membranes acquire deformability, allowing the mature cells to pass through the sinusoidal wall into the sinuses of the bone marrow from where they enter the circulation.

Hematopoietic growth factors:

Various growth factors have been shown to be required for the survival, proliferation, differentia­tion and maturation of hemapoietic cells in culture. Originally these growth factors or a host of cytokines [proteins made cells that affect the behaviour (growth, function) of other cells a medi­ator of communication between the cells) were detected in serum or in conditioned medium from in vitro (outside the living system) cell-cultures.

Effect of Cytokines on Haematopoietic Cells:

They subsequently were defined on the basis of their ability to stimulate the formation of hemo­poietic cell colonies in bone marrow cultures. Among the cytokines, there was a family of acidic glycoproteins, the colony stimulating fac­tors (CSFs), the name given for their ability to induce the formation of distinct hemopoietic cell lineages. These CSFs act in a stepwise manner including proper maturation of hemopoietic cells.

Classes of colony stimulting factors (CSFs):

CSFs can be classified under four distinct cate­gories:

1. Multi-lineage stimulating factor:

Multi-CSF is also known as interleukin 3(IL-3).

This group acts during early differentiation, induces the formation of all non-lymphoid cells including erythrocyte, monocytes and granulo­cyte.

2. Granulocyte-macrophage colony stimu­lating factor (Gm-CSF):

GM-CSF acts slightly in later stage but also induces the formation of non-lymphoid cells.

3. Macrophage-colony-stimulating factor (M-CSF).

4. Granulocyte-colony-stimulating factor (G-CSF).

These two groups help to promote the forma­tion of neutrophil and monocyte.

Besides these four groups, some other impor­tant cytokines take part in the hematopoiesis.

(i) Erythropoietin, this cytokines induces terminal erythrocyte development, regu­lates red blood cells production

(ii) lnterleukin-4 (IL-4)—promotes TH2 differentiation

(iii) IL-5— induces eosinophil activation and generation

(iv) IL-6—influences adaptive immunity

(v) IL-7— the main function is T-cell survival

(vi) IL-8— induces the neutrophil to extravasate into the tissues

(vii) IL-9—it is a third signal transducing subunit.

Control/Regulation of Hematopoiesis:

Haematopoiesis is a continuous process which a steady state of the production and loss of red and white blood cells. Haematopoiesis is regu­lated by complex mechanism that affect all of the individual cell type.

The overall regulatory mechanisms are repre­sented below schematically:

Cells of the Immune System:

The central cell of the immune system is the lymphocyte, which account for roughly 25% of the white blood cells in blood and 99% of the cells in the lymph. A variety of white blood cells or leukocytes, participate in the development of an immune response.

Of these cells, only the lymphocytes possess the attributes of diversity, specificity, memory and self/non-self recog­nition, the hallmark of an immune response. All other cells play accessory roles, serving to activate lymphocytes, to increase the effectiveness of antigen clearance by phagocytosis or to secrete vari­ous immune effector molecules. During hematopoiesis, four major cell linea­ges arise from the HSC’s.


What books to read regarding immunology, developmental biology and stem cells?

Hey, I am a bio major and very interested in the fields of immunology, developmental biology and a topic in particular - Stem Cells. If you could suggest some books regarding these, may not be strictly text books but those that you personally have enjoyed and would prefer. Thanks in advance!

In your case Iɽ go for reviews from journals rather then books. They are more up to date and more specific to a topic. If you want to read a good book that covers these topics Iɽ recommend Albert's Molecular Biology of the Cell

Ah yes, "The Big Pink Book That Won't Go Away". Or I guess it's blue now, but genuinely a great textbook.

for immunology I am currently reading Abbas immunology and I find it quite impressive. I mean the easy to understand way in which the texts have been explained. Any such other books in your mind?

I suppose this depends on your understanding of immunology, but I was required to read How the Immune System Works by Sompayrac before my first class in immunology. It really goes deep into the basics of immunology and is a good foundation if you plan to continue studying immunology in the future. It's also a short and easy read with only about 110 pages or so.

I've also used Contemporary Clinical Immunology and Serology, but it focuses heavily on testing performed in the medical laboratory.

I am yet to have my first immunology class and yes I plan to study immunology in future and then one of my seniors suggested Abbas Immunology and so I started with it. It starts with basics only and goes deeper down the concepts and is quite easily explained, but I appreciate your suggestion and will also try to go through it. Thanks!

Do you mean like science communication/popsci style books? I mean stuff written for the general/lay (but scientifically inclined) audience, as opposed to text books or actual research articles.

I don't know much about developmental biology or stem cells, but there's at least one such immunology book that I think is approachable for a non-expert - The Compatibility Gene by Dan Davis, which very nicely goes through the history of the field and the importance of many key discoveries.

There are only a couple of other ones that I can think of. Tending Adam's Garden by Irun Cohen is great, but pretty technical and philosophical, which may make for dense reading for someone who isn't already fairly well acquainted with immunology or systems level science. There's also a book that I suppose just about counts - The Beginner's Guide to Winning the Nobel Prize by Peter Doherty, although it's not the smoothest read IMHO and is frankly more about the Nobel Prize process (which is fair enough, given the name).

While not strictly immunology, there are loads of good books about the related fields of infectious disease and vaccinology research if you're interested.

Another slightly related popular science book I recommend is The Immortal Life of Henrietta Lacks by Rebecca Skloot, which chronicles the development of modern cell culture, with a particular focus on the development of the HeLa cell line.


Computational Immunology: Applications 1st Edition

Computational Immunology: Applications focuses on different mathematical models, statistical tools, techniques, and computational modelling that helps in understanding complex phenomena of the immune system and its biological functions. The book also focuses on the latest developments in computational biology in designing of drugs, targets, biomarkers for early detection and prognosis of a disease. It highlights the applications of computational methods in deciphering the complex processes of the immune system and its role in health and disease.

    • This book discusses the most essential topics, including
      • Next generation sequencing (NGS) and computational immunology
        • Computational modelling and biology of diseases
          • Drug designing
            • Computation and identification of biomarkers
              • Application in organ transplantation
                • Application in disease detection and therapy

                S Ghosh is MSc, PhD, PGDHE, PGDBI, is PhD from IICB, CSIR, Kolkata, awarded the prestigious National Scholarship from the Government of India. She has worked and published extensively in glycobiology, sialic acids, immunology, stem cells and nanotechnology. She has authored several publications that include books and encyclopedia chapters in reputed journals and books.


                Download link for Immunology, Infection, and Immunity, 9781555812829

                Store Search search Title, ISBN and Author Immunology, Infection, and Immunity by Lee Wexler, Gerald Pier, Jeffrey Lyczak Estimated delivery 3-12 business days Format Hardcover Condition Brand New Examines the basic molecular and cellular components of the immune system relative to the pathogenesis and prevention of infectious diseases Concentrates on the way in which the immune system is critical to the pathogenesis and prevention of infectious diseases Focuses on primary and acquired immuno-d

                author gerald pier author jeffrey lyczak author lee wexler format hardback language english publication year 01 01 2004 subject medicine subject 2 clinical medicine professional title immunology infection and immunity author pier gerald b editor lyczak jeffrey b editor wetzler lee m editor publisher amer society for microbiology publication date apr 01 2004 pages 718 binding hardcover edition 1 st dimensions 9 00 wx 11 25 hx 1 50 d isbn 1555812465 subject health fitness general description thi

                Categories: Immunology->Handbooks, manuals, etc., Immunity. Contributors: Mary J. Ruebush - Author. Format: Multimedia

                Categories: Immunology->Handbooks, manuals, etc., Immunity. Contributors: Mary J. Ruebush - Author. Format: Multimedia


                The Limits of the Self: Immunology and Biological Identity

                What counts as an individual in the living world? What does it mean for a living thing to remain the same through time while constantly changing? Immunology, one of the most dynamic fields of today’s biology, considers these questions its province, and answers them through its crucial concepts of “self” and “nonself.” Though immunology has been dominated since the 1940s by the self-nonself theory, this book argues that this theory is inadequate, because immune responses to self constituents and immune tolerance of foreign entities are the rule, not the exception. An alternative theory, the con . More

                What counts as an individual in the living world? What does it mean for a living thing to remain the same through time while constantly changing? Immunology, one of the most dynamic fields of today’s biology, considers these questions its province, and answers them through its crucial concepts of “self” and “nonself.” Though immunology has been dominated since the 1940s by the self-nonself theory, this book argues that this theory is inadequate, because immune responses to self constituents and immune tolerance of foreign entities are the rule, not the exception. An alternative theory, the continuity theory, is advanced instead. This theory offers a new way to answer the question of what triggers an immune response. It also echoes the recent realization that all organisms, and not higher vertebrates only, have an immune system. This book’s main thesis is that the self-nonself theory should be abandoned, but that immunology still proves to be decisive for delineating the boundaries of the organism. Articulating an evolutionary and an immunological perspective, it offers an original conception of the organism. Tolerance of the fetus by the mother and of countless bacteria on the body’s surfaces proves that every organism is heterogeneous, that is, made of entities of different origins. In other words, every organism appears as a chimera, a mixed living thing the cohesiveness of which is ensured by the constant action of its immune system. The Limits of the Self will be essential reading for anyone interested in the definition of biological individuality and the understanding of the immune system.


                Atlas of Immunology PDF

                The Atlas of Immunology is designed to provide a pictorial reference and serve as a primary resource for the most up-to-date and thorough illustrated treatise available in the complex science of immunology. The book contains more than 1,000 illustrations and depicts essentially every concept of importance in understanding the subject matter of immunology. It is addressed to immunologists and nonimmunologists alike, including students, researchers, practitioners, and basic biomedical scientists. Use of the book does not require prior expertise. Some of the diagrams illustrate basic concepts, whereas others are designed for the specialist interested in a more detailed treatment of the subject matter of immunology. The group of illustrations is relatively complete and eliminates the need to refer to another source. The subject matter ranges from photographs of historical figures to molecular structures of recently characterized cytokines, the major histocompatibility complex molecules, immunoglobulins, and molecules of related interest to immunologists.
                The subject matter is divided into chapters that follow an outline that correlates with a standard immunology textbook. This provides for a logical and sequential presentation and gives the reader ready access to each part of the subject matter as it relates to the other parts of the publication. These descriptive illustrations give the reader a concise and thorough understanding of basic immunological concepts that often intersect the purview of other basic and clinical scientific disciplines. A host of new illustrations, such as cellular adhesions molecules, is presented in a manner that facilitates better understanding of their role in intercellular and immune reactions. Figures that are pertinent to all of the immunological subspecialties, such as transplantation, autoimmunity, immunophysiology, immunopathology, antigen presentation, the T-cell receptor, to name a few, may be found in this publication. Those individuals with a need for ready access to a visual image of immunological information will want this book to be readily available in their bookshelf. No other publication provides the breadth or detail of illustrated immunological concepts as may be found in the Atlas of Immunology.

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                Immunology Made Ridiculously Simple

                Author: Massoud Mahmoudi

                A brief, clear overview of the basic science and clinical aspects of immunology. For medical students and other health professionals. The basic science section is a clear presentation of innate and adaptive immunity, immune cells, antibodies and antigens, and other components of the immune system and their interactions. The clinical section clarifies hypersensitivity, autoimmunity, immunodeficiency, common diagnostic tests, vaccination, transplantation, and tumor immunology, all in 85 pages!


                Humoral Immunity of Immune Response | Immunology

                In this article we will discuss about the humoral immunity of immune response.

                The immune system protects the body from potentially harmful substances by recognizing and responding to antigens. Antigens are foreign particles, normally large or small molecules on the surface of cells, viruses, fungi or bacteria. Some non-living substances such as toxins, chemicals, drugs and foreign particles can also be antigens. Substances that contain these antigens are recog­nized and destroyed by the immune system.

                One of the most important immune response is humoral effector response. The effector func­tions in humoral immunity are mainly mediated by secreted antibodies. It protects body from extra-cellular pathogenic agents by combining with them to form antigen-antibody complex and gradually leads towards their elimination.

                Humoral immunity combats extracellular bacte­ria, fungi and even obligate intra-cellular microbes e.g. viruses before they infect their target T-cells. Any defect in humoral immunity results in increased susceptibility to infection with bacteria and fungi.

                Ways involved in Humoral Immunity:

                Humoral effector functions facilitate effective elimination of foreign pathogens from a host ani­mal in a variety of ways.

                Antibodies play vital role in elimination of antigenic agents:

                (i) The antibody can bind to the surface epi­topes of the antigen making it more sus­ceptible to phagocytosis—known as opsonization.

                (ii) The antibody molecule can bind to the anti­gen forming an antigen-antibody complex, which then combines with the comple­ment in a step-wise manner to initiate and facilitate phagocytosis of the antigen.

                (iii) The antibody can bind to toxin molecules elaborated by microbes making them non­toxic.

                (iv) Antibodies can inactivate free virus parti­cles by combining with the epitopes on viral particles to make them incapable of attachment to host cell membranes.

                (v) Binding to potential pathogens at mucous membrane surfaces, preventing coloniza­tion.

                (vi) Binding to Fc (fragment crystalized) recep­tors on NK cells or macrophages in anti­body dependent cell mediated cytotoxicity (ADCC), confirming specificity for anti­gen.

                Humoral Immune Responses:

                Most defenses that are mediated by antibody present in the plasma, lymph and tissue fluids are called humoral immune responses. It protects against extra-cellular bacteria and foreign macro­molecules. Transfer of antibodies confers this type of immunity on the recipient. Humoral immune responses have an acti­vation phase and an effector phase.

                These phases occur as follows (Fig. 10.1):

                1. The antigen is taken up by phagocytosis and degraded in a lysosome in an APC, such as a macrophage.

                2. A T-cell receptor recognizes processed anti­gen bound to a class II MHC protein on the macrophage.

                3. Cytokines released by the TH cell and IL-1 released by macrophage stimulate the TH cell to produce a clone of differentiated cells capa­ble of interacting with B-cells.

                Activation phase occurs in lymphatic tissue.

                4. B-cells are also antigen presenting cells. Binding of antigen to a specific IgM receptor triggers receptor mediated endocytosis, degradation and display of the processed antigen on class II MHC proteins.

                5. When a TH cell receptor binds to the dis­played antigen—MHC II complex on the B cell, it releases cytokines.


                Immunology MCQ-01 Immunology MCQ for CSIR NET Life Science Exam, Dec – 2017

                (4). Select the false statement about T cells.
                a. T cells do not produce the IL-2
                b. T cells will not respond to IL-4
                c. T cells will not respond to IL-2
                d. T cell mediate their functions only through cell to cell contact

                (5). Which among the following can inhibit inflammation?

                a. RO
                b. TNFα
                c. Neuropeptide Y
                d. Protein C

                (6). The antigen presentation by endogenous pathway involves:
                a. Antigen presentation to cytotoxic T cells
                b. Antigen presentation to Th-1 cells
                c. Antigen presentation to B cells
                d. Antigen presentation on MHC Class II

                (7). Select the wrong statement from the following regarding the receptors of innate immune system:
                a. They are included in the Toll family of receptors
                b. They include MHC complexes
                c. They recognize the molecular patterns
                d. They include scavenger receptors

                (8). The cytotoxic T cells recognize antigen in association with ________.
                a. Class I MHC determinants
                b. Class II MHC determinants
                c. Class III MHC determinants
                d. Class I and Class II Determinants

                (9). A cytokine which can increase the body temperature directly ____.
                a. IL-2
                b. IL-3
                c. IL-5
                d. IL-6

                (10). Which of the following statement is true about TNF alpha?
                a. Can increase the expression of adhesion molecules
                b. Decrease vascular permeability
                c. Evoke Th cells
                d. Induce TGF beta production

                (11). Which of the following statement is true about IgM of human?

                a. IgM can cross the placenta
                b. IgM is produced by high affinity plasma cells
                c. IgM is primarily restricted in the circulation
                d. IgM can protect mucosal surface

                (12). The heavy chain of Immunoglobulin molecules are:

                a. Encoded by a constant region exon
                b. Expressed by T cells
                c. No glycosylated
                d. Heavily phosphorylated

                (13). Presence of ______ can be used to separate helper T cells from cytotoxic T cells.

                a. Class II MHC
                b. CD-2
                c. CD-3
                d. CD-4

                You may also like: Immunology PPTs

                (14). A chemokine with indirect antiviral activity:

                (15). INFγ are primarily produced by ______

                a. NK cells
                b. Th-1 cells
                c. Macrophages
                d. Both (a) and (b)
                e. Both (b) and (c)

                Biology / Life Sciences MCQ: Immunology MCQ01: (Multiple Choice Questions / Model Questions / Sample Questions in Immunology: Introduction with answer key for preparing CSIR JRF NET Life Science Examination and also for other competitive examinations in Life Science / Biological Science such as ICMR JRF Entrance Exam, DBT BET JRF Exam, GATE (XL) Life Science Exam, GATE (BT) Biotechnology Exam, ICAR JRF Exam, University PG Entrance Exam, JAM Exam, GS Biology Exam, GRE, Medical Entrance Examination etc. This set of practice questions will help to build your confidence in Immunology to face the real examination. A large quantum of questions in our practice MCQ is taken from previous year question papers of various national and international Biology / Life Sciences competitive examinations. Please take advantage of our Lecture Notes, PPTs, Previous Year Questions, Mock Tests, and Video Tutorials for your preparation.

                1. Ans. (b). Allergy

                2. Ans. (a). Polysaccharides of bacterial origin

                3. Ans. (c). They do not binds to soluble proteins

                4. Ans. (d). T cell mediate their functions only through cell to cell contact

                5. Ans. (d). Protein C

                6. Ans. (a). Antigen presentation to cytotoxic T cells

                7. Ans. (b). They include MHC complexes

                8. Ans. (a). Class I MHC determinants

                9. Ans. (d). IL-6

                10. Ans. (a). Can increase the expression of adhesion molecules

                11. Ans. (c). IgM is primarily restricted in the circulation

                12. Ans. (a). Encoded by a constant region exon


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